CDB15:0001429 CRIPTO — GPC1

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Macaque, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

A Nodal- and ALK4-independent signaling pathway activated by Cripto-1 through Glypican-1 and c-Src.

Cancer research, 2003; PubMed, Homo sapiens CRIPTO — Homo sapiens GPC1

ABSTRACT: Human Cripto-1 (CR-1) is a member of the epidermal growth factor-Cripto FRL1 Cryptic family that has been shown to function as a coreceptor with the type I Activin serine-threonine kinase receptor ALK4 for the transforming growth factor beta-related peptide Nodal. However, CR-1 can also activate the mitogen-activated protein kinase and Akt pathways independently of Nodal and ALK4 by an unknown mechanism. Here, we demonstrate that CR-1 specifically binds to Glypican-1, a membrane-associated heparan sulfate proteoglycan, and activates the tyrosine kinase c-Src, triggering the mitogen-activated protein kinase and Akt signaling pathways. Finally, an active Src kinase is necessary for CR-1 to induce in vitro transformation and migration in mouse mammary epithelial cells.

Basic Information on CRIPTO

Ligand Name: cripto, EGF-CFC family member

Other Symbols: TDGF1, CR, Cripto-1, CR-1

Ligand Location: secreted based on hpa, perplexity, uniprot, cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: CRIPTO

GeneCards: CRIPTO

HGNC Gene Group: unknown

Functional Annotations for CRIPTO

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for CRIPTO

CRIPTO — ACVR1B ・ CRIPTO — ACVR1C ・ CRIPTO — ACVR2A ・ CRIPTO — ACVR2B ・ CRIPTO — CDON ・ CRIPTO — LRP2 ・ CRIPTO — TGFBR1

Basic Information on GPC1

Receptor Name: glypican 1

Other Symbols: glypican

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: GPC1

GeneCards: GPC1

HGNC Gene Group: MicroRNA host genes, Proteoglycans

Functional Annotations for GPC1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for GPC1

APP — GPC1 ・ COL18A1 — GPC1 ・ SLIT1 — GPC1 ・ SLIT2 — GPC1 ・ VEGFA — GPC1 ・ LRRTM4 — GPC1 ・ SHH — GPC1