CDB25:0003377 COL1A1 — LAIR1

Experimentally validated in Human, Mixed species; Orthology-inferred in Human, Mouse, Rat, Frog, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1.

The Journal of experimental medicine, 2006; PubMed, Homo sapiens COL1A1 — Homo sapiens LAIR1

ABSTRACT: Collagens are the most abundant proteins in the human body, important in maintenance of tissue structure and hemostasis. Here we report that collagens are high affinity ligands for the broadly expressed inhibitory leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1). The interaction is dependent on the conserved Gly-Pro-Hyp collagen repeats. Antibody cross-linking of LAIR-1 is known to inhibit immune cell function in vitro. We now show that collagens are functional ligands for LAIR-1 and directly inhibit immune cell activation in vitro. Thus far, all documented ligands for immune inhibitory receptors are membrane molecules, implying a regulatory role in cell-cell interaction. Our data reveal a novel mechanism of peripheral immune regulation by inhibitory immune receptors binding to extracellular matrix collagens.

Basic Information on COL1A1

Ligand Name: collagen type I alpha 1 chain

Other Symbols: OI4

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: COL1A1

GeneCards: COL1A1

HGNC Gene Group: Collagens

Functional Annotations for COL1A1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for COL1A1

COL1A1 — CD44 ・ COL1A1 — DDR1 ・ COL1A1 — DDR2 ・ COL1A1 — ITGA1 ・ COL1A1 — ITGA11 ・ COL1A1 — ITGA2 ・ COL1A1 — ITGAV ・ COL1A1 — ITGB1 ・ COL1A1 — GP6 ・ COL1A1 — OSCAR

Basic Information on LAIR1

Receptor Name: leukocyte associated immunoglobulin like receptor 1

Other Symbols: CD305, LAIR-1

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: LAIR1

GeneCards: LAIR1

HGNC Gene Group: CD molecules, Immunoglobulin superfamily domain containing

Functional Annotations for LAIR1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for LAIR1

SFTPD — LAIR1 ・ ADIPOQ — LAIR1 ・ ANGPTL1 — LAIR1 ・ ANGPTL7 — LAIR1 ・ C1QA — LAIR1 ・ C1QB — LAIR1 ・ C1QC — LAIR1 ・ COL17A1 — LAIR1 ・ COL3A1 — LAIR1 ・ COLEC12 — LAIR1