CDB15:0000308 CNTF — LIFR

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

The N-terminal cytokine binding domain of LIFR is required for CNTF binding and signaling.

FEBS letters, 2005; PubMed, Homo sapiens CNTF — Homo sapiens LIFR

ABSTRACT: Ciliary neurotrophic factor (CNTF) forms a functional receptor complex containing the CNTF receptor, gp130, and the leukemia inhibitory factor receptor (LIFR). However, the nature and stoichiometry of the receptor-mediated interactions in this complex have not yet been fully resolved. We show here that signaling by CNTF, but not by LIF or oncostatin M (OSM), was abolished in cells overexpressing a LIFR mutant with the N-terminal cytokine binding domain deleted. Our results illustrate molecular differences between the CNTF active receptor complex and those of LIF and OSM and provide further support for the hexameric model of the CNTF receptor complex.

Basic Information on CNTF

Ligand Name: ciliary neurotrophic factor

Other Symbols: HCNTF

Ligand Location: secreted based on perplexity

HGNC Gene Symbol Report: CNTF

GeneCards: CNTF

HGNC Gene Group: Interleukin 6 type cytokine family

Functional Annotations for CNTF

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for CNTF

CNTF — CNTFR ・ CNTF — IL6R ・ CNTF — IL6ST

Basic Information on LIFR

Receptor Name: LIF receptor subunit alpha

Other Symbols: CD118

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: LIFR

GeneCards: LIFR

HGNC Gene Group: MicroRNA host genes, CD molecules, Fibronectin type III domain containing

Functional Annotations for LIFR

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for LIFR

CLCF1 — LIFR ・ CTF1 — LIFR ・ LIF — LIFR ・ OSM — LIFR ・ FAM3C — LIFR