CDB25:0003344 CLEC4G — PILRA

Experimentally validated in Human; Orthology-inferred in Rat, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset

Title

Journal:; Year Published:

Abstract

PILRα negatively regulates mouse inflammatory arthritis.

Journal of immunology, 2014; PubMed, Homo sapiens CLEC4G — Homo sapiens PILRA

ABSTRACT: Paired Ig-like type 2 receptor (PILR)α inhibitory receptor and its counterpart PILRβ activating receptor are coexpressed on myeloid cells. In this article, we report that PILRα, but not PILRβ, is elevated in human rheumatoid arthritis synovial tissue and correlates with inflammatory cell infiltration. Pilrα(-/-) mice produce more pathogenic cytokines during inflammation and are prone to enhanced autoimmune arthritis. Correspondingly, engaging PILRα with anti-PILRα mAb ameliorates inflammation in mouse arthritis models and suppresses the production of proinflammatory cytokines. Our studies suggest that PILRα mediates an important inhibitory pathway that can dampen inflammatory responses.

Basic Information on CLEC4G

Ligand Name: C-type lectin domain family 4 member G

Other Symbols: UNQ431, LSECTIN

Ligand Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: CLEC4G

GeneCards: CLEC4G

HGNC Gene Group: C-type lectin domain containing

Functional Annotations for CLEC4G

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for CLEC4G

CLEC4G — LAG3 ・ CLEC4G — TYROBP

Basic Information on PILRA

Receptor Name: paired immunoglobin like type 2 receptor alpha

Other Symbols: FDF03

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: PILRA

GeneCards: PILRA

HGNC Gene Group: Immunoglobulin superfamily domain containing

Functional Annotations for PILRA

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for PILRA

CD99 — PILRA ・ COLEC12 — PILRA ・ NPDC1 — PILRA ・ PIANP — PILRA