CDB25:0003339 CKLF — CCR4

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Sheep

Title

Journal:; Year Published:

Abstract

Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4).

Life sciences, 2006; PubMed, Homo sapiens CKLF — Homo sapiens CCR4

ABSTRACT: Chemokine-like factor 1 (CKLF1) exhibits chemotactic effects on leukocytes. Its amino acid sequence shares similarity with those of TARC/CCL17 and MDC/CCL22, the cognate ligands for CCR4. The chemotactic effects of CKLF1 for CCR4-transfected cells could be desensitized by TARC/CCL17 and markedly inhibited by PTX. CKLF1 induced a calcium flux in CCR4-transfected cells and fully desensitized a subsequent response to TARC/CCL17, and TARC/CCL17 could partly desensitize the response to CKLF1. CKLF1 caused significant receptor internalization in pCCR4-EGFP transfected cells. Taken together, CKLF1 is a novel functional ligand for CCR4.

Basic Information on CKLF

Ligand Name: chemokine like factor

Other Symbols: CKLF1, UCK-1, CKLF3, CKLF4, HSPC224, C32

Ligand Location: secreted based on hpa, perplexity, uniprot, cell membrane based on perplexity

HGNC Gene Symbol Report: CKLF

GeneCards: CKLF

HGNC Gene Group: unknown

Functional Annotations for CKLF

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for CKLF

Basic Information on CCR4

Receptor Name: C-C motif chemokine receptor 4

Other Symbols: CC-CKR-4, CMKBR4, CKR4, k5-5, ChemR13, CD194

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: CCR4

GeneCards: CCR4

HGNC Gene Group: 7TM proteins, CD molecules

Functional Annotations for CCR4

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for CCR4

CCL17 — CCR4 ・ CCL22 — CCR4 ・ CCL2 — CCR4 ・ CCL3 — CCR4 ・ CCL5 — CCR4