CDB25:0003290 CD72 — CD6

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Soluble CD72, is a T-cell activator probably via binding to CD6 in homeostasis and autoimmunity.

Frontiers in immunology, 2024; PubMed, Homo sapiens CD72 — Homo sapiens CD6

ABSTRACT: CD72 is a highly required regulatory molecule in B cells. Its sufficient expression is crucial for maintaining self-tolerance. In contrast, soluble CD72 (sCD72) is reported to be increased in the serum of autoimmune diseases such as systemic lupus erythematosus and primary Sjogren's syndrome (pSS).

Basic Information on CD72

Ligand Name: CD72 molecule

Other Symbols: LYB2, CD72b

Ligand Location: cell membrane based on perplexity

HGNC Gene Symbol Report: CD72

GeneCards: CD72

HGNC Gene Group: C-type lectin domain containing, CD molecules

Functional Annotations for CD72

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for CD72

CD72 — CD5

Basic Information on CD6

Receptor Name: CD6 molecule

Other Symbols: Tp120

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: CD6

GeneCards: CD6

HGNC Gene Group: Scavenger receptor cysteine rich domain containing, CD molecules

Functional Annotations for CD6

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for CD6

ALCAM — CD6 ・ CDCP1 — CD6