CDB20:0002640 CD209 — ICAM3
Experimentally validated in Human; Orthology-inferred in Zebrafish, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset
Title
Journal:; Year Published:
Abstract
Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses.
Cell, 2000; PubMed, Homo sapiens CD209 — Homo sapiens ICAM3
ABSTRACT: Contact between dendritic cells (DC) and resting T cells is essential to initiate a primary immune response. Here, we demonstrate that ICAM-3 expressed by resting T cells is important in this first contact with DC. We discovered that instead of the common ICAM-3 receptors LFA-1 and alphaDbeta2, a novel DC-specific C-type lectin, DC-SIGN, binds ICAM-3 with high affinity. DC-SIGN, which is abundantly expressed by DC both in vitro and in vivo, mediates transient adhesion with T cells. Since antibodies against DC-SIGN inhibit DC-induced proliferation of resting T cells, our findings predict that DC-SIGN enables T cell receptor engagement by stabilization of the DC-T cell contact zone.