CDB15:0000261 CCL5 — GPR75

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse

Title

Journal:; Year Published:

Abstract

RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75.

British journal of pharmacology, 2006; PubMed, Homo sapiens CCL5 — Homo sapiens GPR75

ABSTRACT: RANTES is an inflammatory chemokine with a critical role in T-lymphocyte activation and proliferation. Its effects are mediated through G protein-coupled heptahelical receptors (GPCRs). We show for the first time that RANTES activates the orphan G protein-coupled receptor 75 (GPR75).

Basic Information on CCL5

Ligand Name: C-C motif chemokine ligand 5

Other Symbols: D17S136E, SCYA5, RANTES, SISd, TCP228, MGC17164

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: CCL5

GeneCards: CCL5

HGNC Gene Group: Receptor ligands: Chemokine ligands

Functional Annotations for CCL5

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for CCL5

CCL5 — ACKR2 ・ CCL5 — CCR1 ・ CCL5 — CCR3 ・ CCL5 — CCR4 ・ CCL5 — CCR5 ・ CCL5 — ACKR1 ・ CCL5 — SDC1 ・ CCL5 — SDC4 ・ CCL5 — CCR10 ・ CCL5 — CCRL2 ・ CCL5 — DPP4

Basic Information on GPR75

Receptor Name: G protein-coupled receptor 75

Other Symbols: WI-31133

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: GPR75

GeneCards: GPR75

HGNC Gene Group: 7TM proteins

Functional Annotations for GPR75

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for GPR75