CDB15:0000229 CCL28 — ACKR2

Experimentally validated in Human, Mouse; Orthology-inferred in Human, Rat, Zebrafish, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Mouse

Title

Journal:; Year Published:

Abstract

Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2).

The Journal of biological chemistry, 2000; PubMed, Homo sapiens CCL28 — Homo sapiens ACKR2

ABSTRACT: We report the identification and characterization of a novel CC chemokine designated CCL28 and its receptor CCR10, known previously as orphan G-protein-coupled receptor GPR2. Human and mouse CCL28 share 83% identity at the amino acid and 76% at the nucleic acid levels. We also identified the mouse homologues of CCL28 and of CCR10, which map to mouse chromosomes 13 and 11, respectively. CCL28 is expressed in a variety of human and mouse tissues, and it appears to be predominantly produced by epithelial cells. Both human and mouse CCL28 induce calcium mobilization in human and mouse CCR10-expressing transfectants. CCL28 desensitized the calcium mobilization induced in CCR10 transfectants by CCL27, indicating that these chemokines share this new chemokine receptor. In vitro, recombinant human CCL28 displays chemotactic activity for resting CD4 or CD8 T cells.

Basic Information on CCL28

Ligand Name: C-C motif chemokine ligand 28

Other Symbols: SCYA28, MEC, CCK1

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: CCL28

GeneCards: CCL28

HGNC Gene Group: Receptor ligands: Chemokine ligands

Functional Annotations for CCL28

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for CCL28

CCL28 — CCR10 ・ CCL28 — CCR3 ・ CCL28 — ACKR5

Basic Information on ACKR2

Receptor Name: atypical chemokine receptor 2

Other Symbols: CMKBR9, CCBP2, CCR10, D6, CCR9

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: ACKR2

GeneCards: ACKR2

HGNC Gene Group: 7TM proteins

Functional Annotations for ACKR2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for ACKR2

CCL11 — ACKR2 ・ CCL13 — ACKR2 ・ CCL14 — ACKR2 ・ CCL2 — ACKR2 ・ CCL3 — ACKR2 ・ CCL4 — ACKR2 ・ CCL5 — ACKR2 ・ CCL7 — ACKR2 ・ CCL8 — ACKR2 ・ CCL17 — ACKR2 ・ CCL22 — ACKR2 ・ CCL3L1 — ACKR2 ・ CXCL10 — ACKR2