CDB25:0003252 CCL18 — GPER1

Experimentally validated in Human; Orthology-inferred in Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Sheep

Title

Journal:; Year Published:

Abstract

Interaction Between CCL18 and GPR30 Differs from the Interaction Between Estradiol and GPR30.

Anticancer research, 2020; PubMed, Homo sapiens CCL18 — Homo sapiens GPER1

ABSTRACT: C-C motif chemokine ligand 18 (CCL18) is overexpressed in the microenvironment of tumors, promotes invasion and metastasis and is thus important for the therapeutic outcome of many tumor entities. The Gs-coupled seven-transmembrane receptor GPR30 is known as both a CCL18 and an estrogen receptor; its activation by estradiol leads to a transactivation of membrane-tethered pro-heparin-binding EGF-like growth factor and the MAPK/ERK pathway. We examined whether this signaling pathway remains the same under CCL18 stimulation, as opposed to estradiol stimulation.

Basic Information on CCL18

Ligand Name: C-C motif chemokine ligand 18

Other Symbols: SCYA18, DC-CK1, PARC, AMAC-1, DCCK1, MIP-4, CKb7

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: CCL18

GeneCards: CCL18

HGNC Gene Group: Receptor ligands: Chemokine ligands

Functional Annotations for CCL18

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for CCL18

CCL18 — CCR3 ・ CCL18 — CCR8 ・ CCL18 — PITPNM3 ・ CCL18 — ACKR1

Basic Information on GPER1

Receptor Name: G protein-coupled estrogen receptor 1

Other Symbols: CMKRL2, GPR30, GPER, FEG-1, GPCR-Br, LERGU, LERGU2, DRY12, LyGPR, CEPR

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: GPER1

GeneCards: GPER1

HGNC Gene Group: 7TM proteins

Functional Annotations for GPER1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for GPER1