CDB20:0002612 CADM1 — NECTIN3

Experimentally validated in Mouse; Orthology-inferred in Human, Rat, Frog, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Cell adhesion molecule 1 (CADM1) on mast cells promotes interaction with dorsal root ganglion neurites by heterophilic binding to nectin-3.

Journal of neuroimmunology, 2012; PubMed, Mus Musculus Cadm1 — Mus Musculus Nectin3

ABSTRACT: Cell adhesion molecule 1 (CADM1) on mast cells promotes attachment and communication with neurons by homophilic binding. However, we found that mast cell CADM1 was responsible for both the attachment of mast cells to dorsal root ganglia (DRG) neurites and their calcium responses to activated DRG neurites, despite the low expression of CADM1 in DRG. Instead, nectin-3 was expressed on DRG neurons and localized to regions of cell-cell contact. A neutralizing antibody to nectin-3 inhibited both mast cell attachment and subsequent calcium responses. This suggests that heterophilic binding between CADM1 and nectin-3 mediates functional DRG-mast cell interactions in vitro.

Basic Information on CADM1

Ligand Name: cell adhesion molecule 1

Other Symbols: TSLC1, IGSF4, NECL2, ST17, BL2, SYNCAM, IGSF4A, Necl-2, SYNCAM1, RA175

Ligand Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: CADM1

GeneCards: CADM1

HGNC Gene Group: Ig-like cell adhesion molecule family, Immunoglobulin superfamily domain containing

Functional Annotations for CADM1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for CADM1

CADM1 — CADM1 ・ CADM1 — CADM3 ・ CADM1 — CRTAM ・ CADM1 — CADM2 ・ CADM1 — CADM4

Basic Information on NECTIN3

Receptor Name: nectin cell adhesion molecule 3

Other Symbols: PVRL3, nectin-3, PPR3, PVRR3, DKFZP566B0846, CDw113, CD113

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: NECTIN3

GeneCards: NECTIN3

HGNC Gene Group: Ig-like cell adhesion molecule family, CD molecules, Immunoglobulin superfamily domain containing

Functional Annotations for NECTIN3

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for NECTIN3

CADM3 — NECTIN3 ・ NECTIN1 — NECTIN3 ・ PVR — NECTIN3