CDB15:0000164 C4BPA — CD40

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

C4b-binding protein (C4BP) activates B cells through the CD40 receptor.

Immunity, 2003; PubMed, Homo sapiens C4BPA — Homo sapiens CD40

ABSTRACT: We demonstrate that the alpha chain of human C4b binding protein (C4BP) binds directly to CD40 on human B cells at a site that differs from that used by CD40 ligand. C4BP induces proliferation, upregulation of CD54 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells from patients with CD40 or IKKgamma/NEMO deficiencies. Furthermore, C4BP colocalized with B cells in the germinal centers of human tonsils. These observations suggest that C4BP is an activating ligand for CD40 and establish a novel interface between complement and B cell activation.

Basic Information on C4BPA

Ligand Name: complement component 4 binding protein alpha

Other Symbols: C4BP

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: C4BPA

GeneCards: C4BPA

HGNC Gene Group: Sushi domain containing, Complement system

Functional Annotations for C4BPA

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for C4BPA

C4BPA — LRP1

Basic Information on CD40

Receptor Name: CD40 molecule

Other Symbols: TNFRSF5, p50, Bp50

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: CD40

GeneCards: CD40

HGNC Gene Group: CD molecules, Tumor necrosis factor receptor superfamily

Functional Annotations for CD40

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for CD40

CD40LG — CD40 ・ LGALS9 — CD40