CDB25:0003189 C1QA — DDR1

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Complement C1q stimulates the progression of hepatocellular tumor through the activation of discoidin domain receptor 1.

Scientific reports, 2018; PubMed, Homo sapiens C1QA — Homo sapiens DDR1

ABSTRACT: C1q is known to perform several functions in addition to the role it plays in complement activation. C1q contains a collagen-like portion and DDR1 (discoidin domain receptor 1) is a well-known collagen receptor. Accordingly, we hypothesized C1q might be a novel ligand of DDR1. This study shows for the first time C1q directly induces the activation and upregulation of DDR1, and that this leads to enhanced migration and invasion of HepG2 cells. In addition, C1q was found to induce the activations of mitogen-activated protein kinases (MAPKs) and phosphoinositide 3-kinase (PI3K)/Akt signaling, and to increase the expressions of matrix metalloproteinases (MMP2 and 9). Our results reveal a relationship between C1q and DDR1 and suggest C1q-induced DDR1 activation signaling may be involved in the progression of hepatocellular carcinoma.

Basic Information on C1QA

Ligand Name: complement C1q A chain

Other Symbols: N/A

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: C1QA

GeneCards: C1QA

HGNC Gene Group: C1q domain containing, Complement system

Functional Annotations for C1QA

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for C1QA

C1QA — CD93 ・ C1QA — CR1 ・ C1QA — CD33 ・ C1QA — ADCY5 ・ C1QA — ADGRB1 ・ C1QA — CD44 ・ C1QA — GPR62 ・ C1QA — LAIR1 ・ C1QA — LRP1 ・ C1QA — MET

Basic Information on DDR1

Receptor Name: discoidin domain receptor tyrosine kinase 1

Other Symbols: NTRK4, PTK3A, NEP, CAK, EDDR1, RTK6, CD167

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: DDR1

GeneCards: DDR1

HGNC Gene Group: MicroRNA host genes, Receptor kinases, CD molecules

Functional Annotations for DDR1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for DDR1

COL1A1 — DDR1 ・ COL2A1 — DDR1 ・ COL3A1 — DDR1 ・ COL5A2 — DDR1 ・ COL1A2 — DDR1 ・ COL4A1 — DDR1 ・ COL4A2 — DDR1 ・ COL4A3 — DDR1 ・ COL4A4 — DDR1 ・ COL4A5 — DDR1 ・ COL4A6 — DDR1 ・ COL5A1 — DDR1 ・ COL5A3 — DDR1