CDB20:0002603 BST2 — LILRA4

Experimentally validated in Human; Orthology-inferred in Rat, Macaque, Chimp, Horse, Marmoset

Title

Journal:; Year Published:

Abstract

Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction.

The Journal of experimental medicine, 2009; PubMed, Homo sapiens BST2 — Homo sapiens LILRA4

ABSTRACT: Plasmacytoid dendritic cells (pDCs) produce copious type I interferon (IFN) upon sensing nucleic acids through Toll-like receptor (TLR) 7 and TLR9. Uncontrolled pDC activation and IFN production are implicated in lymphopenia and autoimmune diseases; therefore, a mechanism controlling pDC IFN production is essential. Human pDCs specifically express an orphan receptor, immunoglobulin-like transcript 7 (ILT7). Here, we discovered an ILT7 ligand expressed by human cell lines and identified it as bone marrow stromal cell antigen 2 (BST2; CD317). BST2 directly binds to purified ILT7 protein, initiates signaling via the ILT7-FcepsilonRIgamma complex, and strongly inhibits production of IFN and proinflammatory cytokines by pDCs. Readily induced by IFN and other proinflammatory cytokines, BST2 may modulate the human pDC's IFN responses through ILT7 in a negative feedback fashion.

Basic Information on BST2

Ligand Name: bone marrow stromal cell antigen 2

Other Symbols: CD317, tetherin, BST-2, HM1.24

Ligand Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: BST2

GeneCards: BST2

HGNC Gene Group: CD molecules

Functional Annotations for BST2

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for BST2

Basic Information on LILRA4

Receptor Name: leukocyte immunoglobulin like receptor A4

Other Symbols: ILT7, CD85g

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: LILRA4

GeneCards: LILRA4

HGNC Gene Group: CD molecules, Immunoglobulin superfamily domain containing

Functional Annotations for LILRA4

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for LILRA4