CDB15:0000085 ARTN — GFRA1

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex.

Neuron, 1998; PubMed, Homo sapiens ARTN — Homo sapiens GFRA1

ABSTRACT: The glial cell line-derived neurotrophic factor (GDNF) ligands (GDNF, Neurturin [NTN], and Persephin [PSP]) signal through a multicomponent receptor system composed of a high-affinity binding component (GFRalpha1-GFRalpha4) and a common signaling component (RET). Here, we report the identification of Artemin, a novel member of the GDNF family, and demonstrate that it is the ligand for the former orphan receptor GFRalpha3-RET. Artemin is a survival factor for sensory and sympathetic neurons in culture, and its expression pattern suggests that it also influences these neurons in vivo. Artemin can also activate the GFRalpha1-RET complex and supports the survival of dopaminergic midbrain neurons in culture, indicating that like GDNF (GFRalpha1-RET) and NTN (GFRalpha2-RET), Artemin has a preferred receptor (GFRalpha3-RET) but that alternative receptor interactions also occur.

Basic Information on ARTN

Ligand Name: artemin

Other Symbols: NBN, EVN, ENOVIN

Ligand Location: secreted based on perplexity, uniprot

HGNC Gene Symbol Report: ARTN

GeneCards: ARTN

HGNC Gene Group: Receptor ligands: GDNF family ligands

Functional Annotations for ARTN

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for ARTN

ARTN — GFRA3 ・ ARTN — RET ・ ARTN — NCAM1 ・ ARTN — SDC3

Basic Information on GFRA1

Receptor Name: GDNF family receptor alpha 1

Other Symbols: GDNFRA, RETL1, GDNFR, GFR-ALPHA-1, RET1L, TRNR1

Receptor Location: cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: GFRA1

GeneCards: GFRA1

HGNC Gene Group: unknown

Functional Annotations for GFRA1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for GFRA1

GDNF — GFRA1 ・ NRTN — GFRA1 ・ PSPN — GFRA1