CDB20:0002589 APOB — ENO1

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Sheep

Title

Journal:; Year Published:

Abstract

Apolipoprotein B binds to enolase-1 and aggravates inflammation in rheumatoid arthritis.

Annals of the rheumatic diseases, 2018; PubMed, Homo sapiens APOB — Homo sapiens ENO1

ABSTRACT: Immune cells from patients with rheumatoid arthritis (RA) express more enolase-1 (ENO1) on their surface than those from healthy subjects, and they elicit an enhanced inflammatory response. This study is aimed to identify the ligands of ENO1 that could promote inflammatory loops in vitro and enhance the arthritis severity in vivo.

Basic Information on APOB

Ligand Name: apolipoprotein B

Other Symbols: ApoB-100

Ligand Location: secreted based on hpa, perplexity, uniprot, cell membrane based on perplexity

HGNC Gene Symbol Report: APOB

GeneCards: APOB

HGNC Gene Group: Apolipoproteins

Functional Annotations for APOB

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for APOB

APOB — LDLR ・ APOB — LRP2 ・ APOB — LRP6 ・ APOB — OLR1 ・ APOB — SCARB1 ・ APOB — TREM2

Basic Information on ENO1

Receptor Name: enolase 1

Other Symbols: ENO1L1, MPB1, ENO1-IT1, PPH, MBP-1

Receptor Location: cell membrane based on hpa, uniprot

HGNC Gene Symbol Report: ENO1

GeneCards: ENO1

HGNC Gene Group: Enolases, MicroRNA host genes

Functional Annotations for ENO1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for ENO1

PLG — ENO1