CDB25:0003111 ANGPTL4 — SDC1

Experimentally validated in Mouse; Orthology-inferred in Human, Rat, Frog, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover.

Developmental cell, 2017; PubMed, Mus Musculus Angptl4 — Mus Musculus Sdc1

ABSTRACT: Angiopoietin-like 4 (ANGPTL4) is a secreted signaling protein that is implicated in cardiovascular disease, metabolic disorder, and cancer. Outside of its role in lipid metabolism, ANGPTL4 signaling remains poorly understood. Here, we identify ANGPTL4 as a Wnt signaling antagonist that binds to syndecans and forms a ternary complex with the Wnt co-receptor Lipoprotein receptor-related protein 6 (LRP6). This protein complex is internalized via clathrin-mediated endocytosis and degraded in lysosomes, leading to attenuation of Wnt/β-catenin signaling. Angptl4 is expressed in the Spemann organizer of Xenopus embryos and acts as a Wnt antagonist to promote notochord formation and prevent muscle differentiation. This unexpected function of ANGPTL4 invites re-interpretation of its diverse physiological effects in light of Wnt signaling and may open therapeutic avenues for human disease.

Basic Information on ANGPTL4

Ligand Name: angiopoietin like 4

Other Symbols: pp1158, PGAR, ARP4, HFARP, FIAF, NL2

Ligand Location: secreted based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: ANGPTL4

GeneCards: ANGPTL4

HGNC Gene Group: Fibrinogen C domain containing, Angiopoietin like family

Functional Annotations for ANGPTL4

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for ANGPTL4

ANGPTL4 — CDH11 ・ ANGPTL4 — CDH5 ・ ANGPTL4 — CLDN5 ・ ANGPTL4 — ITGA5 ・ ANGPTL4 — ITGB1 ・ ANGPTL4 — ITGB5 ・ ANGPTL4 — LEPR ・ ANGPTL4 — NRP2 ・ ANGPTL4 — SDC2 ・ ANGPTL4 — SDC3 ・ ANGPTL4 — SDC4

Basic Information on SDC1

Receptor Name: syndecan 1

Other Symbols: SDC, CD138, syndecan, SYND1

Receptor Location: cell membrane based on perplexity

HGNC Gene Symbol Report: SDC1

GeneCards: SDC1

HGNC Gene Group: CD molecules, Proteoglycans

Functional Annotations for SDC1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for SDC1

CCL5 — SDC1 ・ FGF2 — SDC1 ・ HGF — SDC1 ・ HMGB1 — SDC1 ・ CXCL8 — SDC1 ・ LACRT — SDC1 ・ MDK — SDC1 ・ PTN — SDC1 ・ THBS1 — SDC1 ・ AGRP — SDC1 ・ SCGB3A2 — SDC1 ・ TNFSF13 — SDC1