CDB25:0003086 AGRN — NCAM1

Experimentally validated in Chicken; Orthology-inferred in Human, Mouse, Rat, Frog, Zebrafish, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

NCAM-mediated adhesion of transfected cells to agrin.

Cell adhesion and communication, 1996; PubMed, Gallus gallus AGRN — Gallus gallus NCAM1

ABSTRACT: The vertebrate neural cell adhesion molecule NCAM mediates heterophilic adhesion to heparan sulfate proteoglycans in embryonic chick brain membranes. In this study, mouse L cells transfected with chicken NCAM were used to identify two of these ligands as agrin and the target of the 6C4 monoclonal antibody. A third heparan sulfate proteoglycan, perlecan, appeared not to support NCAM-mediated adhesion. Enzymatic degradation of chondroitin sulfates decreased adhesion in agrin-containing membrane fractions but increased adhesion if the agrin had previously been removed by immunoprecipitation, suggesting that interactions between heparan sulfate and chondroitin sulfate proteoglycans have important influences on adhesion. Our experiments support the view that NCAM can interact with multiple, but not with all, heparan sulfate and chondroitin sulfate proteoglycans in chick brain membranes in both positive and negative ways to influence cell adhesion.

Basic Information on AGRN

Ligand Name: agrin

Other Symbols: AGRIN

Ligand Location: secreted based on hpa, perplexity, uniprot, cell membrane based on hpa, uniprot

HGNC Gene Symbol Report: AGRN

GeneCards: AGRN

HGNC Gene Group: Proteoglycans

Functional Annotations for AGRN

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for AGRN

AGRN — ATP1A3 ・ AGRN — LRP4 ・ AGRN — MUSK ・ AGRN — DAG1 ・ AGRN — ITGAV ・ AGRN — ITGB1 ・ AGRN — PTPRS

Basic Information on NCAM1

Receptor Name: neural cell adhesion molecule 1

Other Symbols: NCAM, CD56

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: NCAM1

GeneCards: NCAM1

HGNC Gene Group: Ig-like cell adhesion molecule family, CD molecules, Fibronectin type III domain containing, Immunoglobulin superfamily domain containing

Functional Annotations for NCAM1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for NCAM1

ARTN — NCAM1 ・ CNTN1 — NCAM1 ・ CNTN2 — NCAM1 ・ GDNF — NCAM1 ・ NCAM1 — NCAM1 ・ NCAN — NCAM1 ・ PRNP — NCAM1 ・ ROBO3 — NCAM1