CDB20:0002563 ADGRB1 — RTN4R

Experimentally validated in Human; Orthology-inferred in Mouse, Rat, Frog, Zebrafish, Chicken, Macaque, Pig, Dog, Cow, Chimp, Horse, Marmoset, Sheep

Title

Journal:; Year Published:

Abstract

Pooled extracellular receptor-ligand interaction screening using CRISPR activation.

Genome biology, 2018; PubMed, Homo sapiens ADGRB1 — Homo sapiens RTN4R

ABSTRACT: Extracellular interactions between cell surface receptors are necessary for signaling and adhesion but identifying them remains technically challenging. We describe a cell-based genome-wide approach employing CRISPR activation to identify receptors for a defined ligand. We show receptors for high-affinity antibodies and low-affinity ligands can be unambiguously identified when used in pools or as individual binding probes. We apply this technique to identify ligands for the adhesion G-protein-coupled receptors and show that the Nogo myelin-associated inhibitory proteins are ligands for ADGRB1. This method will enable extracellular receptor-ligand identification on a genome-wide scale.

Basic Information on ADGRB1

Ligand Name: adhesion G protein-coupled receptor B1

Other Symbols: BAI1

Ligand Location: secreted based on uniprot, cell membrane based on perplexity, uniprot

HGNC Gene Symbol Report: ADGRB1

GeneCards: ADGRB1

HGNC Gene Group: 7TM proteins

Functional Annotations for ADGRB1

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Receptors for ADGRB1

ADGRB1 — RTN4RL1 ・ ADGRB1 — RTN4RL2

Basic Information on RTN4R

Receptor Name: reticulon 4 receptor

Other Symbols: NOGOR

Receptor Location: cell membrane based on hpa, perplexity, uniprot

HGNC Gene Symbol Report: RTN4R

GeneCards: RTN4R

HGNC Gene Group: MicroRNA host genes

Functional Annotations for RTN4R

Gene Ontologies: PAN-GO, AmiGO 2

Expression Profile: Human Protein Atlas (RNA and protein), Human Cell Atlas (RNA), GEPIA cancer vs normal (RNA), GeneCards (RNA and protein)

Disease Annotations: MalaCards, OMIM, Open Targets Platform, DISEASES (text mining), AI summary (LLM)

Interactions with other Ligands for RTN4R

OMG — RTN4R ・ RTN4 — RTN4R ・ MAG — RTN4R ・ RTN2 — RTN4R ・ RTN3 — RTN4R